David B. Rozema;David L. Lewis;James E. Hagstrom;Jason Klein;Jon A. Wolff;Sean D. Monahan;Darren H. Wakefield;So Wong
发明人:
David B. Rozema,James E. Hagstrom,Jason Klein,David L. Lewis,Sean D. Monahan,Darren H. Wakefield,Jon A. Wolff,So Wong
申请号：
US11840468
公开号：
US08137695B2
申请日:
2007.08.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
