NANOCAPSULES DE PROTÉINE À REVÊTEMENT ZWITTERIONIQUE DÉTACHABLE POUR L'ADMINISTRATION DE PROTÉINE

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专利权人:

The Regents of the University of California

发明人:

申请号：

EP16876619.4

公开号：

EP3389641A4

申请日:

2016.12.14

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The invention relates to protein nanocapsules that exhibit material properties that change in different in vivo environments. A zwitterion moiety on the surface of the nanocapsule can protect the protein from opsonization in a first environment, yet uncouples from the protein nanocapsule in a second environment (e.g. at a pH of less than 6.5). In embodiments of the invention, the uncoupled protein nanocarrier is then internalized by mammalian cells (e.g. tumor cells).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/