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DERIVE DE NAPHTYRIDINE
专利权人:
SHIONOGI & CO.; LTD.
发明人:
MITSUOKA, YASUNORI,KOORIYAMA, YUUJI
申请号:
CA2816285
公开号:
CA2816285A1
申请日:
2011.10.27
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
Provided, for example, are a compound described below and the like, which have amyloid ß production inhibitory activity, especially BACE1 inhibitory effect and serve as therapeutic agents for diseases induced by the production, secretion and deposition of amyloid ß protein. A compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt. (In the formula, ring Z represents a substituted or unsubstituted pyridine or a substituted or unsubstituted carbon ring; ring A represents a substituted or unsubstituted carbon ring or a substituted or unsubstituted heterocyclic ring; R1 represents a substituted or unsubstituted alkyl or the like; and R2a, R2b, R4a and R4b each independently represents hydrogen, a substituted or unsubstituted alkyl or the like.)
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