AMJAD ALI,EDWARD METZGER,LIN YAN,MICHAEL MAN-CHU LO
申请号：
BR112012019169
公开号：
BR112012019169A2
申请日:
2011.02.10
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
compound, pharmaceutical composition, and method for treating hypertension in a patient. a compound having the structure or a pharmaceutically acceptable salt thereof, wherein R 4 is hydrogen, -oh, -o-C 1-6 alkyl, = o, or halogen； r ^ 2 ^ is hydrogen, -c (o) or ^ 8 ^, -c ~ 6 ~ h ~ 5 ~ c (o) or ^ 8 ^, - (ch ~ 2 ~) ~ 1 ~ - ~ 2 ~ oh , -cr ^ 9 ^ r ^ 10 ^ oh, -c (o) o (ch ~ 2 ~) ~ 0 ~ - ~ 2-aryl, -c (o) nr ^ 9 ^ r ^ 10 ^, -c ( o) so ~ 2 ~ nr ^ 9 ^ r ^ 10 ^, -c ~ 6 ~ h ~ 5 ~ or ^ 9 ^, -wc (o) or ^ 8 ^, -w-or ^ 9 ^, -y, or -p (o) (or ^ 9 ^) (or ^ 10 ^)； R3 is hydrogen or C1-6 alkyl； R4 is hydrogen, -oh, or -c (o) or -9； R5 is hydrogen or deuterium； R ^ 6 ^ and R ^ 7 ^ are independently C 1-1 alkyl substituted by fluoro, C 1-6 alkyl substituted by deutero or - (ch ~ 2) ~ 1 ~ - 2 ~ wherein any carbon atom of C1-6 alkyl substituted by fluoro is mono- or disubstituted with fluoro and any carbon atom of C1-6 alkyl substituted with deutomer is mono- or disubstituted with fluoro； r ^ 8 ^, in each case where it occurs, is independently hydrogen, -C 1-1 alkyl ~ 6 ~, or - (ch ~ 2 ~) ~ 2 ~ n + (ch ~ 3 ~) ~ 3 ~ ； R ^ 9 ^ and R ^ 10 ^, in each example in which they occur, are independently -C 1-1 alkyl-6-C； R ^ 11 ^ is -oh, -o-alkyl-C 1-1-6-, -ocd-3-, -oc (o) alkyl-C 1-1-6-, -nh ~ 2-, - c ~ 6 ~ h ~ 5 ~, -n ~ 3 ~, or w； w is an unsubstituted 5 or 6 membered heteroaryl ring having 1,2 or 3 nitrogen atoms, or a substituted 5 or 6 membered heteroaryl ring having 1,2 or 3 nitrogen atoms which is mono or di -substituted at any carbon atom with R 6 or R 7； y is a 5 or 6 membered heterocyclic ring having 1,2,3, or 4 heteroatoms which are n, o or s, or stereoisomers thereof, or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable salts of stereoisomers thereof and methods of using the same. compounds to treat hypertension.composto, composição farmacêutica, e, método para tratar hipertensão em um paciente. um composto tendo a estrutura ou um sal farmaceuticamente aceitável d
