Antimalarial compounds with flexible side-chains

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专利权人:

Yongyuth Yuthavong

发明人:

Yongyuth Yuthavong,Tirayut Vilaivan,Sumalee Kamchonwongpaisan,Bongkoch Tarnchompoo,Chawanee Thongpanchang,Penchit Chitnumsub,Jirundon Yuvaniyama,David Matthews,William Charman,Susan Charman,Livia Viva

申请号：

US12247953

公开号：

US08530491B2

申请日:

2008.10.08

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.

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