您的位置: 首页 > 农业专利 > 详情页

METHODS AND COMPOSITIONS FOR DELIVERY TO CNS HEPARAN-N-SULFATASE
专利权人:
ИНК. (US);ШИР ХЬЮМАН ДЖЕНЕТИК ТЕРАПИС
发明人:
НАТОЛИ Фарах (US),ЧЖУ Гаочжун (US),ТЕРЕВ Дженнифер (US),ЦЗЯН Юань (US),ЦУНГ Джеми (US),ШАХРОКХ Захра (US),ВЕРНАГЛИА Брайан (US),ПАН Цзинь (US),ПФАЙФЕР Ричард (US),КАЛИАС Периклс (US)
申请号:
RU2012154576/10
公开号:
RU2012154576A
申请日:
2011.06.25
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A stable composition for intrathecal administration containing heparan-N-sulfatase protein (HNS), salt, buffering agent and polysorbate surfactant. A stable composition according to claim 1, characterized in that the HNS protein is present in a concentration of up to about 100 mg / ml. A stable composition according to claim 1, characterized in that the HNS protein is present in a concentration of up to about 30 mg / ml. A stable composition according to claim 1, characterized in that the HNS protein is present in a concentration from the range of about 10-20 mg / ml. A stable composition according to claim 1, characterized in that the HNS protein is present in a concentration in the range of about 15 mg / ml. The stable composition according to claim 1, characterized in that said protein contains the amino acid sequence of SEQ ID NO: 1.7. A stable composition according to any one of claims 1 to 6, characterized in that the salt is NaCl. 8. A stable composition according to claim 7, characterized in that NaCl is present in a concentration from a range of about 0-300 mM. A stable composition according to claim 8, characterized in that NaCl is present at a concentration of about 100-200 mm. A stable composition according to claim 9, characterized in that NaCl is present at a concentration of about 145 mM. A stable composition according to any one of claims 1 to 6, characterized in that the polysorbate surfactant is selected from the group consisting of polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 80, and combinations thereof. The stable composition according to claim 11, characterized in that the polysorbate surfactant is polysorbate 20.13. A stable composition according to claim 12, characterized in that polysorbate 20 is present in a concentration from a range of about 0-0.05%. Stable composition according to item 13, wherein the polysorbate 20 is present in to1. Стабильный состав для интратекального введения, содержащий белок гепаран-N-сульфатазы
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充