Requirement 1: a stable ethane hydrate formulation to reduce instability, polymerization, misfolding, and / or ethane fragmentation, comprising about 25-75 mg / m of ethane and one or more stabilizers selected from the mixture. A group consisting of (I) sodium chloride and (II) sodium chloride combined with sucrose or trihalogens； and (III) a mixture of sodium chloride, sucrose and trihalogens. Requirement 2: composition according to requirement 1,It also includes one or more additional ingredients selected from the closed solution, a pigment modifier and a prosthetic. 3. Claim 3: the component in line with claim 2, the stabilizer basically includes: (a) sodium chloride； or (b) sodium chloride combined with sucrose； or (c) sodium chloride combined with trichloroethane； in this claim, the stabilizer is prepared optionally, It's free or basically not aginina,e. The long-term storage stability of the preparation is at least one: SEC analysis a m83232o t832222 or t8324de: monomer content is more than about 90%；a. Components with total content less than 3% (wt%) and fragment content less than 5% (wt%): analysis with hic-m8323 or t832222 or t8324, wherein the components represented by peak value of hic-chromatography-1 are less than about 3% (wt%)； Peak 2 of HIC chromatography is more than 80% by weight； peak 3 of HIC chromatography represents less than 20% by weight. 11. Claim 11: the composition in accordance with claim 2, including: about 50 mg / M ethane；approximately 120 mM sodium chloride； approximately 10 to 30 mM sodium phosphate； about 1% by weight sucrose； about 5 mM arginine, and it has a pH of about 6.3 to 6.5. Claim 16: The composition according to claim 1, which does not contain arginine, or is basically free of arginine, wherein the composition, at M₃ or T₂ or T₄, obtains long-term storage stability that meets one or both of the following criteria: (A) stability comparable to, or better than, etanercept commercially available and marketed under the Enbrel®
