Morrison, Robert Kendall,Jakobovits, Aya,Gudas, Jean,Jia, Xiao-Chi,Challita-Eid, Pia M.,Raitano, Arthur B.
申请号：
AU2006237616
公开号：
AU2006237616B2
申请日:
2006.02.15
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response antibodies or T cells reactive with PSCA can be used in active or passive immunization.
