NOUVEL OLIGO-ARN À DOUBLE BRIN ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT POUR LA PRÉVENTION OU LE TRAITEMENT DE LA FIBROSE OU DE MALADIES RESPIRATOIRES
CHAE, Jeiwook,채제욱,YOON, Pyoung Oh,윤평오,HAN, Boram,한보람,KIM, Mi Na,김미나,KO, Youngho,고영호,PARK, Han Oh,박한오
申请号：
KRKR2015/003400
公开号：
WO2015/152693A3
申请日:
2015.04.06
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a novel siRNA, and a highly efficient double-stranded oligo RNA structure and nanoparticles comprising same, wherein the double-stranded oligo RNA structure is one in which a hydrophilic material and a hydrophobic material are conjugated to both terminals of the double-stranded RNA (siRNA) through a simple covalent bond or linker-mediated covalent bond to efficiently transport the double-stranded RNA structure into cells, and the double-stranded RNA structure may be changed into a nanoparticle form in an aqueous solution due to the hydrophobic interaction between the double-stranded RNA structures. The siRNA included in the double-stranded oligo RNA structure is preferably siRNA specific to a fibrosis- or respiratory disease-associated gene - particularly, amphiregulin or stratifin. Further, the present invention relates to a pharmaceutical composition comprising siRNA, and a highly efficient double-stranded oligo RNA structure and nanoparticles comprising same, as an active ingredient for preventing or treating fibrosis or respiratory diseases. Also, the present invention relates to a method for preventing or treating fibrosis or respiratory diseases including administering the pharmaceutical composition for preventing or treating fibrosis or respiratory diseases to a subject in need thereof.La présente invention concerne un nouveau siARN, et une structure d'oligo-ARN double brin à haute efficacité et des nanoparticules le comprenant, ladite structure d'oligo-ARN double brin comportant un matériau hydrophile et un matériau hydrophobe conjugués aux deux extrémités de l'ARN double brin (siARN) par une liaison covalente simple ou une liaison covalente médiée par un lieur, pour transporter efficacement la structure d'ARN double brin dans des cellules. En outre, la structure d'ARN double brin peut être modifiée en une forme nanoparticulaire dans une solution aqueuse sous l'effet de l'interaction hydrophobe entre les structures d'ARN doub
