CHAE JEIWOOK,YOON PYOUNG OH,HAN BORAM,KIM MI NA,KO YOUNGHO,PARK HAN OH
申请号：
IN201647037304
公开号：
IN201647037304A
申请日:
2016.11.01
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to a novel siRNA and a highly efficient double stranded oligo RNA structure and nanoparticles comprising same wherein the double stranded oligo RNA structure is one in which a hydrophilic material and a hydrophobic material are conjugated to both terminals of the double stranded RNA (siRNA) through a simple covalent bond or linker mediated covalent bond to efficiently transport the double stranded RNA structure into cells and the double stranded RNA structure may be changed into a nanoparticle form in an aqueous solution due to the hydrophobic interaction between the double stranded RNA structures. The siRNA included in the double stranded oligo RNA structure is preferably siRNA specific to a fibrosis or respiratory disease associated gene particularly amphiregulin or stratifin. Further the present invention relates to a pharmaceutical composition comprising siRNA and a highly efficient double stranded oligo RNA structure and nanoparticles comprising same as an active ingredient for preventing or treating fibrosis or respiratory diseases. Also the present invention relates to a method for preventing or treating fibrosis or respiratory diseases including administering the pharmaceutical composition for preventing or treating fibrosis or respiratory diseases to a subject in need thereof.
