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WT1-ANTIGEN PEPTIDE CONJUGATE VACCINE
专利权人:
LTD.;SUMITOMO DAINIPPON PHARMA CO., LTD.;SUMITOMO DAINIPPON PHARMA CO.;INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC
发明人:
LI, CHIANG JIA,BAN, HITOSHI,NISHIO, YUKIHIRO,GOTO, MASASHI,NISHIHARA, TOSHIO,TAKANASHI, YOSUKE
申请号:
PH12015502180
公开号:
PH12015502180A1
申请日:
2015.09.17
申请国别(地区):
PH
年份:
2016
代理人:
摘要:
The present invention provides a compound expressed by formula (1) or a salt, etc., thereof. In formula (1): Xa and Ya represent single bonds, etc.; a cancer antigen peptide (A) represents an MHC class I-restrictive WT1 peptide comprising a 7-30 residue amino acid; R1 represents a hydrogen atom, a group expressed by formula (2) (in the formula, Xb and Yb represent single bonds, etc., and a cancer antigen peptide (B) represents an MHC class I-restrictive WT1 peptide comprising a 7-30 residue amino acid and having a different sequence to that of the cancer antigen peptide (A)), or a cancer antigen peptide (C); and a cancer antigen peptide (C) represents an MHC class I-restrictive WT1 peptide or an MHC class II-restrictive WT1 peptide that comprise a 7-30 residue amino acid which contains one cysteine residue, and have a different sequence to that of the cancer antigen peptide (A)
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