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WT1 antigen peptide conjugate vaccine
专利权人:
SUMITOMO DAINIPPON PHARMA CO., LTD.;INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC.
发明人:
Chiang Jia Li,Hitoshi Ban,Yukihiro Nishio,Masashi Goto,Toshio Nishihara,Yosuke Takanashi
申请号:
US14549091
公开号:
US09181302B2
申请日:
2014.11.20
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A compound represented by the formula (1):wherein Xa and Ya are each a single bond and the like, cancer antigen peptide A is an MHC class I-restricted WT1 peptide consisting of 7-30 amino acid residues, R1 is a hydrogen atom, a group represented by the formula (2):wherein Xb and Yb are each a single bond and the like, cancer antigen peptide B has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide consisting of 7-30 amino acid residues, or cancer antigen peptide C, and cancer antigen peptide C has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide or an MHC class II-restricted WT1 peptide, consisting of 7-30 amino acid residues containing one cysteine residue, or a salt thereof, and the like.
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