HAFNER, ROD,LAIDLER, PAUL,LAYTON, GUY,LARCHE, MARK
申请号：
NZ59426810
公开号：
NZ594268A
申请日:
2010.02.05
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
594268 Disclosed is a composition suitable for use in preventing or treating allergy to grass pollen by tolerisation, comprising: (a) the polypeptide Tim07B (KIPAGELQIIDKIDA) or a variant thereof； (b) the polypeptide Ber0l (SGKAFGAMAKKGQED) or a variant thereof； and (c) the polypeptide Bio04A (LKKAVTAMSEAEK) or a variant thereof； wherein a variant of a polypeptide is: I) a longer polypeptide of up to 30 amino acids in length which comprises the sequence of the said polypeptide specified in (a), (b) or (c)； or II) a polypeptide of 9 to 30 amino acids in length that is capable of binding to an MHC class II molecule and which comprises a sequence that has at least 70% homology to the sequence of the said polypeptide specified in (a), (b) or (c)； or III) a polypeptide of 9 to 30 amino acids in length that is capable of binding to an MHC class II molecule and which comprises: at least 9 contiguous amino acids of the sequence of the said polypeptide specified in (a), (b) or (c)； or a sequence that has at least 70% homology to said at least 9 contiguous amino acids.
