PROBLEM TO BE SOLVED: To provide an oil-in-water type emulsified composition for in a high density containing a sparingly soluble medicament, for being excellent, and suitable for being suitable as the stability and an injection, and the production method.SOLUTION: An oil-in-water emulsion composition containing a poorly-soluble drug having emulsified particles with an average particle diameter of less than 500 nm contains a poorly-soluble drug having a solubility in water of less than 1 mg/mL with a molecular weight of equal to or more than 500, an oil constituent containing medium chain fatty acid triglycerides in an amount of more than 80 mass% and an amount of more than 6 mass% with respect to the mass of the entire composition, and a surfactant constituent containing phospholipids in an amount of equal to or more than 50 mass%.COPYRIGHT: (C)2012,JPO&INPIT【課題】難溶性薬物を高濃度に含有すると共に、良好な安定性で且つ注射剤として好適な水中油型乳化組成物及びその製造方法を提供する。【解決手段】水への溶解度が1mg/mL未満であり、かつ分子量が500以上の難溶性薬物と、80質量%を超える量で中鎖脂肪酸トリグリセリドを含有し、且つ組成物の全質量に対して6質量%を超える量の油成分と、50質量%以上の量でリン脂質を含有する界面活性剤成分と、を含み、乳化粒子の平均粒子径が500nm未満である難溶性薬物含有水中油型乳化組成物。【選択図】なし
