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SOLID DISPERSION OF DUTASTERIDE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
专利权人:
KOREA PRIME PHARM CO.; LTD.
发明人:
Dae Ik KIM,Woo Cheoul SHIN
申请号:
US16761990
公开号:
US20200306266A1
申请日:
2018.11.12
申请国别(地区):
US
年份:
2020
代理人:
摘要:
A solid dispersion of dutasteride for improving the solubility or dissolution rate of poorly soluble dutasteride, a method for preparing the solid dispersion, and a pharmaceutical composition including the solid dispersion are provided. The solid dispersion includes: a coprecipitate including dutasteride and a water-soluble polymeric carrier; and an adsorbent. The dutasteride and the water-soluble polymeric carrier are present in a weight ratio of 1:10-100 in the coprecipitate. The solid dispersion exhibits a dissolution rate equal to or higher than AVODART® soft capsules and contains a minimal amount of related substances, achieving good storage stability.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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