A compound of formula Q: ** Formula ** in which (i) R1 is H or C1-6 alkyl； (ii) R2 is C1-6 alkyl, C3-8 cycloalkyl optionally substituted with one or more amino, C3-8 heterocycloalkyl optionally substituted with C1-6 alkyl, C0-6 alkylaminoC0-6 alkyl, -GJ wherein: G is alkylene C1-6； J is C3-6 cycloalkyl or C3-6 heterocycloalkyl optionally substituted with C1-6 alkyl； (iii) R3 is D-E-F wherein 1. D is a single bond, C1-6 alkylene or C1-6 arylalkylene； 2. E is a C1-6 alkylene, arylene, C1-6 alkylarylene, C1-6 aminoalkylene or amino； and 3. F is C3-8 heterocycloalkyl optionally substituted with C1-6 alkyl； (iv) R4 is aryl optionally substituted with one or more halo, hydroxy or C1-6 alkoxy； heteroaryl or C3-6 heterocycloalkyl； and (v) R5 is H, C1-6 alkyl, C3-8 cycloalkyl, heteroaryl, aryl or biphenyl-4-ylmethyl； wherein "aryl" or "arylene" is an aromatic, mono or bicyclic hydrocarbon optionally substituted with C1-6 alkyl, halogen, C1-6 haloalkyl, hydroxy, carboxy or an additional aryl or heteroaryl； and "heteroaryl" is an aromatic moiety in which one or more of the atoms constituting the aromatic ring is sulfur or nitrogen instead of carbon, heteroaryl or heteroarylene which may optionally be substituted with C1-6 alkyl, halogen, C1-6 haloalkyl , hydroxy or carboxy； in free or saline form.Un compuesto de formula Q:**Fórmula** en la que (i) R1 es H o alquilo C1-6； (ii) R2 es alquilo C1-6, cicloalquilo C3-8 opcionalmente sustituido con uno o mas amino, heterocicloalquilo C3-8 opcionalmente sustituido con alquilo C1-6, alquilamino C0-6alquilo C0-6, -G-J en donde: G es alquileno C1-6； J es cicloalquilo C3-6 o heterocicloalquilo C3-6 opcionalmente sustituido con alquilo C1-6； (iii) R3 es D-E-F en donde 1. D es un enlace sencillo, alquileno C1-6 o arilalquileno C1-6； 2. E es un alquileno C1-6, arileno, alquilarileno C1-6, aminoalquileno C1-6 o amino； y 3. F es heterocicloalquilo C3-8 opcionalmente sustituido con alquilo C1-6； (iv) R4 es arilo opcionalmente sustituido con uno
