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Endogenous neogenesis of beta cells
专利权人:
发明人:
George Gittes,Ping Guo,Xiangwei Xiao
申请号:
US15305083
公开号:
US10071172B2
申请日:
2015.04.17
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Methods are disclosed for producing pancreatic beta cells in a subject. The methods include administering to the subject a vector encoding heterologous Pancreas duodenal homeobox protein (Pdx) 1 and MafA, wherein the vector does not encode Neurogenin 3 (Ngn3) and wherein the subject is not administered any other nucleic acid encoding Ngn3. The vector is administered intraductally into a pancreatic duct of the subject. Compositions are disclosed that include a) a viral vector comprising a promoter operably linked to a nucleic acids encoding Pdx1 and a nucleic acid encoding MafA, wherein the vector does not encode Ngn3 b) a buffer and c) a contrast dye for endoscopic retrograde cholangiopancreatography. These compositions are of use in any of the methods disclosed herein.
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