Patrick Aubourg,Nathalie Cartier-Lacave,Eloise Hudry
申请号：
US12678020
公开号：
US08198257B2
申请日:
2008.09.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to a viral vector for treating Alzheimers disease, which vector comprises a cholesterol 24-hydroxylase (CYP46A1) encoding nucleic acid. In a preferred embodiment, the viral vector may be an Adeno-Associated-Virus (AAV) vector, preferably an AVV5 vector. The vector may be useful for the manufacture of a pharmaceutical composition for the treatment of Alzheimers disease in a subject, wherein the vector is to be administered directly into the brain of the subject or by intravenous or intrathecal injection.
