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VECTORS AND METHODS FOR REGENERATIVE THERAPY
专利权人:
UNIVERSITY OF WASHINGTON
发明人:
W. Robb MACLELLAN,Danny EL-NACHEF
申请号:
US15566987
公开号:
US20180117125A1
申请日:
2016.04.20
申请国别(地区):
US
年份:
2018
代理人:
摘要:
An expression vector capable of disrupting the silencing of cell cycle genes in adult cells, such as adult cardiac myocytes and other quiescent cells in terminally differentiated tissues, comprising: (a) a nucleic acid sequence encoding lysine-specific demethylase 4D (KDM4D); (b) a promoter that induces or effects overexpression of KDM4D, wherein the promoter is operably linked to the nucleic acid sequence; and (c) a regulatory element that inducibly represses the overexpression of KDM4D. The vector can be administered to a subject in a method for inducing tissue-specific hyperplasia in a mammal, including cardiomyocyte proliferation. The method provides for regenerative therapy, including improving cardiac function after myocardial infarct and other forms of cardiac damage.
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