The present invention relates to polycyclic derivatives, preparation processes and pharmaceutical use thereof. Specifically, the present invention relates to novel polycyclic derivatives of general formula (I), preparation processes and pharmaceutical compositions containing the same, as well as their use as a therapeutic agent, especially their use as a GPR40 agonist and in the preparation of a medicament for the treatment of diabetes, metabolic syndrome X, and so on, wherein all substitutes of general formula (I) are defined as those in the specification.本發明涉及多環類衍生物、其製備方法及其在醫藥上的應用。具體而言，本發明涉及一種通式(I)所示的新的多環類衍生物、其製備方法及含有該衍生物的藥物組合物以及其作為治療劑，特別是作為GPR40促效劑和在製備治療糖尿病和代謝性病症等疾病的藥物中的用途，其中通式(I)的各取代基與說明書中的定義相同。
