Gel composition comprises methylparaben (0.05-0.20 wt.%), one or more second preservatives, a carbomer (0.80-1.50 wt.%), and total polyol (9-13 wt.%), where the topical gel composition has a pH of 4.5-7.5, and when the concentration of methylparaben is greater than 0.15 wt.%, the concentration of carbomer is less than 1.25 wt.%. Gel composition comprises: either methylparaben (0.05-0.20 wt.%), one or more second preservatives, a carbomer (0.80-1.50 wt.%), and total polyol (9-13 wt.%)； brimonidine (0.05-5 wt.%), methylparaben (0.05-0.20 wt.%), one or more second preservatives, a carbomer (0.80-1.50 wt.%), and total polyol (9-13 wt.%), where the topical gel composition has a pH of 4.5-7.5, and when the concentration of methylparaben is greater than 0.15 wt.%, the concentration of carbomer is less than 1.25 wt.%； or brimonidine tartrate (0.1-0.6 wt.%), methylparaben (0.05-0.15 wt.%), one or more second preservatives are sodium benzoate, phenoxyethanol, benzyl alcohol, imidazolidinyl urea or diazolidinyl urea, carbomer (0.80-1.50 wt.%), propylene glycol (4.5-6.5 wt.%), glycerol (4.5-6.5 wt.%), and purified water, where the pH of the topical gel composition is adjusted to 5-6.5 by an adequate amount of sodium hydroxide aqueous solution. ACTIVITY : Dermatological； Vasotropic； Antipsoriatic； Hemostatic； Antiseborrheic； Antiinflammatory； Muscular-Gen.； Cytostatic； Osteopathic； Cerebroprotective； Gastrointestinal-Gen. MECHANISM OF ACTION : None given.La présente invention concerne des compositions de gel topique améliorées, telles que celles contenant de la brimonidine pour le traitement de troubles cutanés. Les compositions de gel contiennent un carbomère et du méthylparabène, et sont sensiblement exemptes de particules cristallines de méthylparabène après une période de conservation prolongée.
