PROBLEM TO BE SOLVED: To provide a liquid preparation sterilization method that can satisfy the sterility assurance level 10-6, can sufficiently suppress a decrease in the concentration of active ingredients, and is applicable to a wide range of liquid preparations.SOLUTION: A liquid preparation sterilization method comprises the step of irradiating a liquid preparation (excluding a protein preparation and a synthetic polymer preparation) in a frozen state with radiation.COPYRIGHT: (C)2014,JPO&INPIT【課題】無菌性保証水準10-6を満たすことができ、有効成分濃度の低下を十分に抑制することができ、広範囲の液体製剤に適用可能な液体製剤の滅菌方法を提供する。【解決手段】凍結状態の液体製剤(タンパク質製剤及び合成高分子製剤を除く)に、放射線を照射する工程を含む、液体製剤の滅菌方法。【選択図】なし
