Thomas W. Jr. DUBENSKY,David B. KANNE,Meredith Lai Ling LEONG,Laura Hix GLICKMAN,Russell E.VANCE,Edward Emile LEMMENS
申请号：
HK16110895.7
公开号：
HK1222512A
申请日:
2016.09.14
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are substantially pure 2&prime,5&prime,2&prime,5&prime and 2&prime,5&prime,3&prime,5&prime CDNs, and preferably Rp,Rp stereosiomers thereof.
