Tamper-resistant oral pharmaceutical dosage form comprising a pharmacologically active ingredient, an opioid antagonist and/or aversive agent, polyalkylene oxide and anionic polymer
BARNSCHEID LUTZ,BARTHOLOMÄUS JOHANNES,GEISSLER ANJA,SCHWIER SEBASTIAN
申请号：
NZ62329112
公开号：
NZ623291A
申请日:
2012.11.15
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Provided is a pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient (ii) an opioid antagonist and/or an aversive agent (iii) a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol and (iv) comprising an anionic polymer and/or having a storage stability at 40°C of at least 3 months. In a preferred embodiment the dosage form includes an anionic polymer, and the aversive agent is selected from (a) substances which irritate the nasal passages and/or pharynx, (b) viscosity-increasing agents and/or gelling agents (c) emetics (d) dyes (e) bitter substances and (f) surfactants.
