Tamper-resistant oral pharmaceutical dosage form comprising a pharmacologically active ingredient, an opioid antagonist and/or aversive agent, polyalkylene oxide and anionic polymer
Geissler, Anja,Barnscheid, Lutz,Schwier, Sebastian,Bartholomaus, Johannes
申请号：
AU2012338872
公开号：
AU2012338872B2
申请日:
2012.11.15
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The invention relates to a pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient； (ii) an opioid antagonist and/or an aversive agent； (iii) a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol； and (a) comprising (iv) an anionic polymer； and/or (b) having a storage stability at 40°C of at least 3 months.
