TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING A PHARMACOLOGICALLY ACTIVE INGREDIENT, AN OPIOID ANTAGONIST AND/OR AVERSIVE AGENT, POLYALKYLENE OXIDE AND ANIONIC POLYMER
GEISSLER, ANJA,BARNSCHEID, LUTZ,SCHWIER, SEBASTIAN,BARTHOLOMUS, JOHANNES
申请号：
HK15101505.9
公开号：
HK1200742A
申请日:
2015.02.11
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The invention relates to a pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient (ii) an opioid antagonist and/or an aversive agent (iii) a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol and (a) further comprising (iv) an anionic polymer and/or (b) having a storage stability at 40° C. of at least 3 months.
