TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING A PHARMACOLOGICALLY ACTIVE INGREDIENT, AN OPIOID ANTAGONIST AND/OR AVERSIVE AGENT, POLYALKYLENE OXIDE AND ANIONIC POLYMER
GEISSLER, ANJA,BARNSCHEID, LUTZ,SCHWIER, SEBASTIAN,BARTHOLOMAUS, JOHANNES
申请号：
CA2855718
公开号：
CA2855718A1
申请日:
2012.11.15
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to a pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient (ii) an opioid antagonist and/or an aversive agent (iii) a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol and (a) comprising (iv) an anionic polymer and/or (b) having a storage stability at 40°C of at least 3 months.
