The present invention relates to amide derivatives inhibitors, preparation methods and uses thereof. Specifically, the invention relates to compounds represented by general formula (I), their preparation methods and pharmaceutical compositions, and their applications as ASK1 inhibitors in the treatment of neurodegenerative diseases, cardiovascular diseases, inflammatory diseases, autoimmune diseases and metabolic diseases. Each substituent in the general formula (I) is defined as that in the specification.本發明涉及醯胺類衍生物抑制劑、其製備方法和應用。特別地，本發明涉及通式(I)所示的化合物、其製備方法及含有該化合物的藥物組成物，及其作為ASK1抑制劑在治療神經退休性疾病、心血管疾病、炎症、自身免疫和代謝性疾病的用途，其中通式(I)中的各取代基與說明書中的定義相同。
