The invention relates to a heteroaromatic derivative regulator, its preparation method and application. In particular, the present invention relates to the compound represented by the general formula (I), its preparation method and pharmaceutical composition containing the compound, and its use as a Janus kinase inhibitor in the treatment of inflammation-related diseases and tumor-related diseases, wherein Each substituent in the general formula (I) has the same definition as in the specification.本發明涉及雜芳類衍生物調節劑、其製備方法和應用。特別地,本發明涉及通式( I )所示的化合物、其製備方法及含有該化合物的藥物組合物,及其作為Janus激酶抑制劑,在治療炎症性相關疾病和腫瘤相關疾病的用途,其中通式( I )中的各取代基與說明書中的定義相同。