Provided are a compound represented by formula (I) or a stereoisomer, hydrate, metabolite, solvate, pharmaceutically acceptable salt, eutectic mixture, or prodrug thereof, and a preparation method thereof, and an application for preparing a pharmaceutical product for treating a disease related to obstructed airways, wherein each substituent in the compound represented by formula (I) is as described in the specification.一種通式(I)所示的化合物或其立體異構物、水合物、代謝產物、溶劑化物、藥學上可接受的鹽、共晶或前藥,以及製備方法及在製備用於治療氣道阻塞性疾病藥物中的應用,其中通式(I)化合物為其中,各取代基的定義與說明書中一致。