The present invention provides a compound shown in a general formula (I) and a general formula (II) or a stereoisomer, a hydrate, a metabolic product, a solvate, salt which is pharmaceutically receivable, eutectic crystals or a prodrug therefor, a preparation method therefor and application therefof in preparing a medicine for treating an airway obstructive disease. The compound in a general formula (I) and a general formula (II) is as shown in a figure, wherein a definition of each substituent group is consistent with that in the description.本發明提供了一種通式(I)和(II)所示的化合物或其立體異構物、水合物、代謝產物、溶劑化物、藥學上可接受的鹽、共晶體或前藥，以及製備方法和在製備用於治療氣道阻塞性疾病藥物中的應用，其中通式(I)和(II)化合物為其中，各取代基的定義與說明書中一致。
