The invention relates to a series of quinoline derivatives of general formula I, pharmaceutically acceptable salts, hydrates, solvates or prodrugs. Thereof M, R 1 , R 2 , X, Y and n are defined as claims. And the compounds of general formula I show potent inhibitory activity gainst c-Met kinase. The present invention further relates to the uses of the compounds, pharmaceutically acceptable salts and hydrates for the preparation of medicaments for the treatment and/or prevention of diseases caused by abnormal expression of c-Met kinase, especially for treatment and/or prevention of cancer.本發明涉及通式I所示的喹啉類衍生物及它們藥學上可接受的鹽、水合物或前藥,其中取代基M、R1、R2、X、Y以及n具有在說明書中給出的含義。本發明還涉及通式I的化合物具有抑制c-Met激酶的作用,並且還涉及該類化合物及其藥學上可接受的鹽、水合物在製備治療由於c-Met激酶異常高表達所引起疾病的藥物中的用途,特別是在製備治療和/或預防癌症的藥物中的用途。
