Provided are novel amine compounds represented by the following general formula (I) or pharmaceutically allowable acid addition salts thereof, or hydrates or solvates thereof, which have excellent action for reducing peripheral blood lymphocytes, excellent immune suppressing action and rejection response suppressing action, and reduced side-effects such as bradycardia.(wherein each symbol represents the same meaning as that described in the specification.)本發明係提供一種具有優異之末梢血淋巴球減少作用、且免疫抑制作用及排斥反應抑制作用等優異、並減輕心搏徐緩等副作用的以下述通式(I)所示之新穎胺化合物、或其製藥上可容許之酸加成鹽、或該等之水合物或溶劑合物：(式中，各符號係與說明書中同義)。
