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Fusokines Involving Cytokines with Strongly Reduced Receptor Binding Affinities
专利权人:
VIB VZW;CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE MONTPELLIER;UNIVERSITEIT GENT;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITÉ MONTPELLIER 2
发明人:
Jan TAVERNIER,Jennyfer BULTNICK,Sarah GERLO,Gilles UZÉ,Franciane PAUL,Yann BORDAT
申请号:
US14905343
公开号:
US20180155404A1
申请日:
2014.07.03
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to a fusion protein comprising at least two cytokines, of which at least one is a modified cytokine with a strongly reduced binding affinity to its receptor, or to one of its receptors. Preferably, both cytokines are connected by a linker, preferably a GGS linker. The invention relates further to said fusion protein for use in treatment of diseases.
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