LIZASOAIN HERNANDEZ, IGNACIO,GONZALEZ MUNOZ, VICTOR MANUEL,FERNANDEZ GOMEZ-CHACON, GERONIMO,MORO SANCHEZ, MARIA ANGELES,MARTIN PALMA, MA ELENA,MORAGA YEBENES, ANA
申请号：
CA2953020
公开号：
CA2953020A1
申请日:
2015.06.24
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates to a nucleic acid aptamer with the capability of binding specifically to and inhibiting TLR-4, to a complex comprising said aptamer and a functional group, as well as to pharmaceutical compositions thereof. The invention also relates to uses and methods for detecting TLR-4 and to uses and methods for inhibiting TLR-4. Finally, the invention also relates to an aptamer for use in manufacturing a drug for the treatment of a pathology characterized by an increase in expression of TLR4 and/or an increase in activation of TLR-4.
