Ignacio LIZASOAIN HERNANDEZ,Victor Manuel GONZALEZ MUÑOZ,Geronimo FERNANDEZ GOMEZ-CHACON,Maria Angeles MORO SANCHEZ,Maria Elena MARTIN PALMA,Ana MORAGA YEBENES
申请号：
US16220726
公开号：
US20190211334A1
申请日:
2018.12.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention relates to a nucleic acid aptamer with the capability of binding specifically to a and inhibiting TLR-4, to a complex comprising said aptamer and a functional group, as well as to pharmaceutical compositions thereof. The invention also relates to uses and methods for detecting TLR-4 and to uses and methods for inhibiting TLR-4. Finally, the invention also relates to an aptamer for use in manufacturing a drug for the treatment of a pathology characterized by an increase in expression of TLR4 and/or an increase in activation of TLR-4.
