Lizasoain Hernandez, Ignacio,Gonzalez Munoz, Victor Manuel,Fernandez Gomez-Chacon, Geronimo,Moro Sanchez, Maria Angeles,Martin Palma, Ma Elena,Moraga Yebenes, Ana
申请号：
AU2015279248
公开号：
AU2015279248A1
申请日:
2015.06.24
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The invention relates to a nucleic acid aptamer with the capability of binding specifically to and inhibiting TLR-4, to a complex comprising said aptamer and a functional group, as well as to pharmaceutical compositions thereof. The invention also relates to uses and methods for detecting TLR-4 and to uses and methods for inhibiting TLR-4. Finally, the invention also relates to an aptamer for use in manufacturing a drug for the treatment of a pathology characterized by an increase in expression of TLR4 and/or an increase in activation of TLR-4.
