To provide a manipulation mechanism capable of reliably fixing an operation wire to an operating object member, endoscope, and manufacturing method.SOLUTION: The manipulation mechanism according to one embodiment of the present invention, includes a sleeve member that is caulked into such a caulked shape as to retain a twisting shape of a plurality of wire strands of an operation wire, so that the sleeve member is caulked, with the wire strands retained in an original line contact state. This configuration can prevent the wire strands from getting into a point contact state and being damaged with each other so as to improve tension strength and bending durability of the operation wire, and reliably fix the operation wire to an operating object member. Further, the sleeve member externally fitted around the operation wire is fixed to the operating object member so as to dispense with another member for fixing, thereby downsizing the fixing member.SELECTED DRAWING: Figure 19【課題】本発明は、操作用ワイヤを被操作部材に確実に固定できる操作機構、内視鏡、及び製造方法を提供することを目的とする。【解決手段】本発明の一の態様に係る操作機構によれば、スリーブ部材を操作用ワイヤの複数の素線の撚り形状が維持されるかしめ形状にかしめることで、素線どうしが元々の線接触状態を維持したままかしめられるので、素線同士が点接触状態になって傷つけ合うことがなく、操作用ワイヤの引張強度及び屈曲耐久性が高くなり、操作用ワイヤを被操作部材に確実に固定することができる。また、操作用ワイヤに外嵌されたスリーブ部材を被操作部材に固定するので、他の固定用部材が不要で固定部分を小型化することができる。【選択図】 図19