ANA LUCIA RELO,ANDREAS HAUPT,JÜRGEN DINGES,KARLA DRESCHER,LILIANE UNGER,ROBERT VAN WATERSCHOOT,WICKE KARSTEN
申请号：
BR112015021471
公开号：
BR112015021471A2
申请日:
2014.03.14
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Summary "Suitable acylaminocycloalkyl compounds for the treatment of disorders responsive to d3 dopamine receptor modulation" The present invention relates to acylaminocycloalkyl compounds, in particular the compounds of formula I as described herein and their salts and n-oxides. The compounds have valuable therapeutic properties and are suitable in particular for treating diseases responsive to dopamine d3 receptor modulation. in formula i, the variables have the following meanings: m is 1 or 2, n is 1 or 2, a is selected from the group consisting of chz, chzchz, chfchz and cfzchz, r1 is a selected oxygen-containing cyclic radical such as as C3-C6 cycloalkyl, which carries one or two oxygen-containing radicals selected from the group consisting of oh, C1-C2 alkoxy, fluorinated C1-C2 alkoxy, and a carbonyl oxygen, R2 is selected from the group consisting of in hydrogen, oh and fluorine, r3a is selected from the group consisting of hydrogen and methyl, r3b is selected from the group consisting of hydrogen and methyl, r4 is branched c4-c6 alkyl or branched fluorinated c4-c6 alkyl, and R5 is inter alia C1-C6 alkyl, fluorinated C1-C3 alkyl, C1-C2-alkoxy C1-C4-alkoxy, C1-C4-C1-4 fluorinated alkoxy, C1-C4-hydroxy-C1-C4-hydroxyalkyl fluorinated, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, cycloalkyl fluorinated c3-c5, etc.resumo “compostos acilaminocicloalquila adequados para o tratamento de distúrbios que respondem à modulação do receptor de dopamina d3” a presente invenção refere-se a compostos acilaminocicloalquila, em particular, aos compostos da fórmula i como descrito aqui e a seus sais e n-óxidos. os compostos possuem propriedades terapêuticas valiosas e são adequados, em particular, para tratar doenças que respondem à modulação do receptor de dopamina d3. na fórmula i, as variáveis têm os seguintes significados: m é 1 ou 2, n é 1 ou 2, a é selecionado a partir do grupo que consiste em chz, chzchz, chfchz e cfzchz, r1 é um radic
