This document refers to the compounds used for treatment, including the components of these compounds and the disease treatment methods including the use of these compounds. These compounds are the modulators of the acetylcholine-acetylcholine-a7 receptor. These compounds can be used to treat Alzheimer's, Alzheimer's and other diseases, epilepsy, post-traumatic memory loss. Claim 1: a compound calculated according to formula (1),a. A8308es c-r8308o n, a8309es c-r8309o N and a8310es c-r8310o n, but at least a83081；a. A8309o a8310se n, but not more than 2 of a83088；A83099 and a8310sean n； R1 is phenyl or isobutylene； in this case, phenyl or isobutylene can replace one or more R1 substitutes,where each R¹¹ is individually selected from C₁₋₆ alkyl,Halogen, hydroxy, halide c832131；C₁₋₆ alkoxy,C₁₋₆ haloalkoxy,ciano alquil C sulfonilo -S (O) NH y -NR Rwhere R¹² and R¹³ independently represent hydrogen or C₁₋₆ alkyl；R² is selected from H, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ alkoxy,Halogen and cyanogen； R3,R830808,R83099,R8310a and r8311a are selected independently；of H, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ alkoxy,Halogen, cyanogen and - nr8313； r183044,where R⁹ and R¹⁰ independently represent hydrogen, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ haloalkyl or phenyl； R⁸ is selected from H, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ alkoxy,Halogens, cyanogens and phenyl, and one of the salts that is medically acceptable.La presente se refiere a compuestos útiles en terapia, a composiciones que comprenden dichos compuestos, y a métodos de tratamiento de enfermedades, que comprenden la administración de dichos compuestos. Los compuestos referidos son moduladores alostéricos positivos (PAM) del receptor de acetilcolina nicotínico a7. Los compuestos son útiles para el tratamiento de la enfermedad de Alzheimer, demencia senil y otras, epilepsia, amnesia postraumática. Reivindicación 1: Un compuesto de acuerdo con la fórmula (1), donde A⁴
