COOK ADAM,GUNAWARDANA INDRANI W.,HUNT KEVIN W.,KALLAN NICHOLAS C.,TANG TONY P.,THOMAS ALLEN A.,HUESTIS MALCOLM,VOLGRAF MATTHEW,SIU MICHAEL,NEWHOUSE BRAD,METCALF ANDREW T.
申请号：
ARP110104345
公开号：
AR083953A1
申请日:
2011.11.22
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
These compounds inhibit the decomposition of Apple by b-secretariat and can be used as therapeutic agents for neurodegenerative diseases. Retification 1: a compound and stereoisomer, tropospheric isomer, corresponding isomer, Tao Qiang meter and pharmaceutically acceptable salt selected from formula (1), wherein W is cr12r13； This is O, s or N1, Z is a link, ch or C (= O),If Z is C (= O), then y is NR1； X1 is selected from O, s, s (o),SO2, N10 and ch10； X2 is selected from cr5r6, NR7 and O； X3 is selected from a link, cr8r9 and O, provided X3 is or X2 is cr5r6； X4 is selected from cr11 and N； X5 is selected from cr14r15 and O, provided X5 is or, X2 is cr5r6 and X3 is cr8r9 or a link； X6 is cr16r17； R1 is selected from hydrogen, selected from hydrogen. 1. Aralquilo, isopropene and isopropenyl； R2 and R3 are hydrogen or alkyl； R4 is hydrogen, hydrogen Xi, halogen, amino, cyanogen, nitrogen, tar, alcox, acilo, aciloxi, aciloxi, acilamino, alcoxicarbio, sulfuric acid, sulfonate, ariloxi, a thyroid gland and a heterocycle, which contain such amine, tar, alcoxi, acilo, aciloxi, Oxygen carbidesulfonyl, sulfinyl, sulfanyl, aryloxy, carbocycle and heterocycle are optionally substituted with SF5, hydroxy, halogen, amino, cyano, nitro, oxo, optionally substituted alkyl, optionally substituted alkoxy, sulfanyl, acyl, alkoxycarbonyl, haloalkyl, optionally substituted carbocycle or heterocycle optionally substituted； R5 and R6 are independently selected from hydrogen, hydroxy, halogen, amino, cyano, nitro, alkyl, alkoxy, acyl, acyloxy, alkoxycarbonyl, sulfonyl, sulfinyl, sulfanyl, aryloxy, a carbocycle and a heterocycle, wherein said alkyl, alkoxy, acyl, acyloxy, alkoxycarbonyl, sulfonyl, sulfinyl, sulfanyl, aryloxy,Choose hydrogen Xi, halogen, ammonia, cyanogen, nitrogen, oxo, alternative tar, alternative alcox, sulfonate, ACIO, alcoxibonilo, halogen tar or alternative carbon, or R5 and R6 together to form an oxo group, O R5 and R6, together with the atoms attached to them, form
