Non-human animals having a humanized programmed cell death 1 gene

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专利权人:

REGENERON PHARMACEUTICALS, INC.

发明人:

Burova Elena,Mujica Alexander O.,Lai Ka-Man Venus,Murphy Andrew J.

申请号：

US201514744592

公开号：

US9955677(B2)

申请日:

2015.06.19

申请国别(地区):

美国

年份:

2018

代理人:

Scully, Scott, Murphy & Presser, P.C. `Zippin Margarita

摘要：

Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. The non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Pdcd1 gene so that the non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/