ALLEN RAU;Donald STADOLIK;Freddy ACOSTA;Melvin CORCINO
发明人:
ALLEN RAU,Donald STADOLIK,Melvin CORCINO,Freddy ACOSTA
申请号：
US13867308
公开号：
US20140315719A1
申请日:
2013.04.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Tablets are prepared with friability reducing agents to yield tablets that are more resistant to breakage or crumbling, but with satisfactory hardness. The friability reducing agents include low molecular weight polyethylene glycol as well as similar agents exhibiting at least three percent (3%) hydroxide moieties and a water solubility of at least eighty percent (80%) (w/w %) in room temperature water. The tablets may comprise an active agent and excipient of almost any type, and about 0.1-about 0.5% by weight friability reducing agent. They exhibit a hardness of at least eighty percent (80%) of the same tablet prepared without the friability reducing agent.
