LIN, PEI CHENG,林培正,林培正,CHANG, HAN HSIN,张菡馨,張菡馨,CHEN, CHIN CHU,陈劲初,陳勁初,LIN, TING WE,林定威,林定威,LEE, LI YA,李丽雅,李麗雅,WU, SZU YIN,吴思颖,吳思穎,CHANG, HSIAO LING,张晓苓,張曉苓
申请号：
TW104122264
公开号：
TWI552755B
申请日:
2015.07.09
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The invention relates to an antrodia camphorate mycelium active material and a preparation method, a medical composition including the same and the usage of the medical composition. The active material is prepared by the following steps (a) cultivating antrodia camphorate mycelia at a preset temperature and a preset pH value for five to seven days (b) inoculating the antrodia camphorate mycelia cultivated in the step (a) into a fermentation tank, and stir cultivating the antrodia camphorate mycelia at the preset temperature and the preset pH value for 7-20 days and (c) freeze drying and grinding the antrodia camphorate mycelia cultivated in the step (b) to form antrodia camphorate mycelium freeze dry powder, mixing a solvent of a preset amount with the antrodia camphorate mycelium freeze dry powder, performing vibration extraction of a mixture and filtering and removing the antrodia camphorate mycelium freeze dry powder to form an antrodia camphorate mycelium extract, and subjecting the antrodia camphorate mycelium extract to vacuum concentration and drying to obtain the antrodia camphorate mycelium active material.本發明關於一種用於預防和/或治療乾眼症之樟芝菌絲體活性物質以及包含該活性物質之醫藥組合物。此活性物質係以下列步驟製備:取一樟芝菌絲體於一預定溫度及一預定pH值下培養5-7天;將步驟(a)培養後之樟芝菌絲體接種至一發酵槽內,於該預定溫度及該預定pH值下攪拌培養約7-20天;將步驟(b)培養後之樟芝菌絲體冷凍乾燥後磨粉,形成一樟芝菌絲體凍乾粉;將一預定量之溶劑與該樟芝菌絲體凍乾粉混合,震盪萃取後過濾移除該樟芝菌絲體凍乾粉,形成一樟芝菌絲體萃取液;以及減壓濃縮並乾燥該樟芝菌絲體萃取液,獲得該樟芝菌絲體活性物質。
