Matthias Eckhardt,Hans-Juergen Martin,Martin Schuehle,Sandra Sick,Bing-Shiou Yang
申请号：
US13289418
公开号：
US20120157488A1
申请日:
2011.11.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds defined by formula Iwherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
