Regeneron Pharmaceuticals, Inc.;Institute for Research in Biomedicine (IRB);Yale University
发明人:
MURPHY, Andrew J.,EYNON, Elizabeth,MANZ, Markus G.,FLAVELL, Richard,Yancopoulos, George D.,STEVENS, Sean,RATHINAM, Chozhavendan
申请号：
DK12746594
公开号：
DK2675271T3
申请日:
2012.02.14
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection； in in vivo screens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state； in in vivo screens for agents that are toxic to hematopoietic cells； in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells； in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc.
