MURPHY ANDREW J,STEVENS SEAN,RATHINAM CHOZHAVENDAN,EYNON ELIZABETH,MANZ MARKUS,FLAVELL RICHARD,YANCOPOULOS GEORGE D
申请号：
IN2492/KOLNP/2013
公开号：
IN2013KN02492A
申请日:
2013.08.09
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
Genetically modified mice comprising a nucleic acid sequence encoding a human M CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M CSF protein that have been engrafted with human cells such as human hematopoietic cells and methods for making such engrafted mice. These mice find use in a number of applications such as in modeling human immune disease and pathogen infection in in vivo screens for agents that modulate hematopoietic cell development and/or activity e.g. in a healthy or a diseased state in in vivo screens for agents that are toxic to hematopoietic cells in in vivo screens for agents that prevent against mitigate or reverse the toxic effects of toxic agents on hematopoietic cells in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy etc.
