REGENERON PHARMACEUTICALS, INC;INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB);YALE UNIVERSITY
发明人:
MURPHY,ANDREW J,STEVEN,SEAN,RATHINAM, CHOZHAVENDAN,EYNON, ELIZABETH,MANZ,MARKUS,FLAVELL, RICHARD,YANCOPOULOS, GEORGE D.,STEVEN SEAN,MANZ MARKUS
申请号:
MYPI 2013002891
公开号:
MY162984A
申请日:
2012.02.14
申请国别(地区):
MY
年份:
2017
代理人:
摘要:
GENETICALLY MODIFIED MICE COMPRISING A NUCLEIC ACID SEQUENCE ENCODING A HUMAN M-CSF PROTEIN ARE PROVIDED. ALSO PROVIDED ARE GENETICALLY MODIFIED MICE COMPRISING A NUCLEIC ACID SEQUENCE ENCODING A HUMAN M-CSF PROTEIN THAT HAVE BEEN ENGRAFTED WITH HUMAN CELLS SUCH AS HUMAN HEMATOPOIETIC CELLS, AND METHODS FOR MAKING SUCH ENGRAFTED MICE. THESE MICE FIND USE IN A NUMBER OF APPLICATIONS, SUCH AS IN MODELING HUMAN IMMUNE DISEASE AND PATHOGEN INFECTION; IN IN VIVO SCREENS FOR AGENTS THAT MODULATE HEMATOPOIETIC CELL DEVELOPMENT AND/OR ACTIVITY, E.G. IN A HEALTHY OR A DISEASED STATE; IN IN VIVO SCREENS FOR AGENTS THAT ARE TOXIC TO HEMATOPOIETIC CELLS; IN IN VIVO SCREENS FOR AGENTS THAT PREVENT AGAINST, MITIGATE, OR REVERSE THE TOXIC EFFECTS OF TOXIC AGENTS ON HEMATOPOIETIC CELLS; IN IN VIVO SCREENS OF HUMAN HEMATOPOIETIC CELLS FROM AN INDIVIDUAL TO PREDICT THE RESPONSIVENESS OF AN INDIVIDUAL TO A DISEASE THERAPY, ETC.