REGENERON PHARMACEUTICALS, INC.; INC.;INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB);YALE UNIVERSITY;REGENERON PHARMACEUTICALS
发明人:
MURPHY, ANDREW J.,STEVENS, SEAN,RATHINAM, CHOZHAVENDAN,EYNON, ELIZABETH,MANZ, MARKUS G.,FLAVELL, RICHARD,YANCOPOULOS, GEORGE D.
申请号:
EP12746594
公开号:
EP2675271A4
申请日:
2012.02.14
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; in in vivo screens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to hematopoietic cells; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc.