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FUSED Heterocyclic derivatives as modulators of S1P
专利权人:
ABBVIE B.V.
发明人:
IWEMA BAKKER, WOUTER I.,SMID, PIETER,COOLEN HEIN K.A.C.,VAN DONGEN, MARIA JOHANNA PETRONELLA,SLIEDREGT, LEONARDUS A.J.M,DEN HARTOG, JACOBUS A.J
申请号:
ECSP13012416
公开号:
ECSP13012416A
申请日:
2013.02.04
申请国别(地区):
EC
年份:
2013
代理人:
摘要:
The present invention relates to the selection of a fused aperiodic derivative of cyanoammonium (c2-4) formula (I) (I) from East Germany 1,Penicillin (C 2-4),1. Asphalt (C-4),Each is replaced by one or more fluorine atoms, cyclopropyl (C3-6)1. Cyclopentadiene (C4-6) or a double cycle group (C8-10);Each substitute is replaced by halogen or tar (c-1-4). The substitute is one or more fluorine atoms, phenyl, biphenyl and northwest Africa. Each substitute is replaced by one or more selected substitutes of non halogen, cyanogen and tar (c-1-4). The substitute is one or more fluorine atoms and oxygen. (C-4) can optionally be replaced by one or more fluorine, amino, diethylamine and cyclopropyl ILO (C 3-6) atoms, substituted by phenyl, can be replaced by hydrocarbon (c-1-4) or halogen, and yfenilo can be replaced by phenyl, benzene, phenyl, phenyl or monocyclic ring, each of which can be replaced by coke oil (c-1-4),Z is a contact group - W - (tar CN) - t - where W is added to R1 and O - is selected from the link,- I...- yes.-So...-SO2...- en...-CH=CH---C (CF3) 3DCH--C? Page: 1-Yeah. - yeah-O-CO-O-O- uh huh...-NH-CO- and trans-cyclopropylene; n is an integer from 0 to 10; and T adheres to the phenylene / pyridyl functional group and is selected from a bond, -O-,- yes.-So...-SO2...- en...- I...-C=C-C? Page: 1R2 is h or one or more substitutes selected from cyanide, halogen, tar (C1-4), which can be replaced by one or more halogen atoms, or oxygen (C1-4) which can be replaced by one or more halogen atoms; the structure of ring a can contain one nitrogen atom; X is selected from If x is C, select R3 from H and tar (C 1-4),otherwise R3 is not present; Y is selected from NH, O and S; structure Q is a 5, 6 or 7 membered cyclic amine; R4 is (C 1-4) alkylene -R5 where one or more carbon atoms in the alkylene group can be independently substituted with one or more halogen atoms or with (CH2) 2 to form a cyclopropyl functional group, or R4 is cycloalkylene (C 3-6) -R5, -CH2-cycloalky
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